Lydia was probably the most famous Pinkham by name, unless you know anything about music, in which case, the most famous Pinkham is her great-grandson the late Daniel Rogers Pinkham. In any case, one of the more controversial things I did in my Pinkham article was to debunk the lineage for the line of Lydia's husband, Isaac Pinkham, as given in the 1908 Pinkham Genealogy. I never found the actual connection to the larger Pinkham family. Isaac Pinkham's father, Daniel pops up in Portsmouth and he is certainly the son of an Isaac Pinkham b. ca. 1760 and Sally Jones. Where the first Isaac fits in, is still a question. In any case, Mrs. Pinkham was famous for her patent medicine for women (called a "vegetable compound" but containing a significant portion of booze).