This is an ancestor I do not descend from, and in fact, no one descends from him. I descend from his nephew. But this is a case where the clues for everyone's relationship have been around for 150 years but it only recently got put together correctly. Therefore, there's many errors in print or on the Internet regarding this family.
1. William Howe born say 1524 and died about January 1588 at Boxted, Essex, England. He married first Alice Aulfield who was buried at Boxted 28 August 1560. He married secondly on 24 November 1560 at Boxted, Catherine Sherren/Shirrin. She was probably the Widow Howe buried on 13 April 1590. William and Alice had four children: William, George, Richard, and Robert. William and Catherine had an additional two children: Edward and Allen.
2. Edward Howe was baptized at Boxted, England 31 August 1561 and buried there February 1591/2. Edward married in 1585 at Boxted to Ann Lumpkin, born say 1564 and died after 1592, daughter of the widow Gibbs. Edward and Ann had three children: Edward, a son, and Mary.
2a. Edward Howe (Jr.) was baptized 1 January 1587/8 at Boxted, Essex, England and died at Watertown, Massachusetts before 24 June 1644. He married at Boxted on 16 August 1610, Margaret Wells, baptized at Boxted 31 May 1590 and died before 18 December 1660 at Charlestown, Massachusetts, daughter of Richard Wells. Margaret married secondly George Bunker of Charlestown who died about 1664. Edward and Margaret were childless. Each left wills and gave their property to Nathaniel Treadway and Ann Stone, who turned out to be their niece and nephew.
2b. Mary Howe was baptized 23 January 1591/2 at Boxted, Essex, England. She married 21 September 1614 at St. Botolph's Church at Colchester, Essex, England, Nathaniel Treadway born about 1585 and died before 1630. Mary and Nathaniel had two children: Nathaniel and Anne, both of whom went to New England. There is now a competing theory that Anne was not a child of Mary and Nathaniel, but a niece of Margaret (Wells) Howe. If you are a John and Anne Stone descendant, beware that this matter has not been adequately proven.
"English Origins of the Howe and Treadway Families of Watertown, Mass." The American Genealogist 70 (1995):171-180.
The Ancestry of Eva Belle Kempton 1878-1908: Part I, The Ancestry of Warren Francis Kempton 1817-1879 by Dean Crawford Smith (Boston, NEHGS, 1996), pp. 337-42.
Robert Charles Anderson The Great Migration Begins; Immigrants to New England 1620-1633 (NEHGS, Boston, 1995), II:1013-1016.
New England Historical & Genealogical Register 3 (1849):77 (the will of Edward Howe).